Previous attempts at noninvasive estimation of pulmonary artery systol
ic pressure (PA(S)) were limited by the inability to identify adequate
spectral signals of tricuspid regurgitation (TR) in a significant pro
portion of patients. Recently, image and color flow directed continuou
s-wave Doppler have enabled spectral mapping of previously undetectabl
e TR jets. Accordingly, 30 consecutive patients underwent two-dimensio
nal and continuous-wave Doppler echocardiograms immediately before rig
ht heart catheterization. PA(S) was calculated as SIGMA (4V2 + RA) whe
re V is the maximal velocity of the TR jet in m/sec and RA is right at
rial pressure as estimated by the caval respiratory index. Twenty-eigh
t patients (93%) had detectable signals of TR. Directly measured PA(S)
ranged from 21 to 95 mmHg (mean +/- SD, 40 +/- 18). Correlation betwe
en Doppler and catheter-measured PA(S) was R - sq = 0.93 with a standa
rd error of the estimate of 4.7 mmHg. Accurate results were obtained o
ver a wide range of pulmonary pressures. Thus, noninvasive determinati
on of PA(S) is feasible in most patients including those with normal P
A(S), and correlates extremely well with direct measurements.