METAGENESIS MODIFIERS AND ANTICARCINOGENE SIS

The problems of anticarcinogenesis are discussed in the context of mec hanistic approaches and the well known mechanisms of multistage carcin ogenesis. Various events at extra- and intracellular levels are involv ed in mutagenesis and carcinogenesis. The most promising candidates fo r suppression of chemical carcinogenesis are some nitrosation modifier s, dietary sorbents, metabolic activation modulators, reactive metabol ite trappers, repair inducers, gene expression inhibitors, etc. Short- term tests for mutagenicity are more preferable for screening potentia l anticarcinogenic agents. The bioassays for anticarcinogenesis should be assessed for sensitivity, specificity and predictability and the g enetic profiles of the antimutagic activity of the modifiers analysed.