INTERGROUP DIFFERENCES OF ANTICLUSTOGENES IS

The paper deals with the mechanisms of anticlustogenesis - protection of chromosomes in cultured human cells, which depend on many external anf internal factors and may vary in genetic risk groups and in indivi duals. It also analyzes the role of repair and metabolic disturbances in the observed inter- and intragroup differences in the effeciency of protective action in model test systems. Results of comparative analy sis of the efficiency of various interferons in the cultured cells fro m patients with bronchial asthma are presented. The paper first provid es evidence for attenuated protective effects in the cultured lymphocy tes from patients with xeroderma pigmentosum or chronic recurrent urti caria as compared to those from healthy donors. Prospects of and optim al methodological approaches to the study of anticlustogenesis in huma n cells are discussed.