RECENT CONTRIBUTIONS OF CARBONYLATION REACTION TO THE SYNTHESIS OF FLUORINATED PHARMACEUTICAL COMPOUNDS

Several organofluorine compounds endowed with unique pharmaceutical ac tivity, such as fluorinated aminoacids, fluorinated artylpropanoic aci ds, etc. can be conveniently prepared by hydroformylation, hydrocarbox ylation and hydroesterification of appropriated olefins containing one or more fluorine atoms in definite positions of the molecule. Many or ganic-fluorinated compounds obtained by carbonylation procedures repre sent very useful intermediates for the synthesis of pharmacologically active molecules, as for instance: fluor-indoles, fluor beta-lactams a nd fluor uracils.