HYPOTHALAMIC HAMARTOMA CAUSING PRECOCIOUS PUBERTY TREATED BY SURGERY - CASE-REPORT

A 6-year-old girl was treated for precocious puberty secondary to a hy pothalamic hamartoma by resection of the tumor. When she was six month s old, her parents noticed incipient pubic hair and menses accompanied by breast development. Computed tomography was judged as normal. The girl was treated with monthly gonadotropin-releasing hormone analogue injections until 6 years of age, when magnetic resonance imaging (MRI) demonstrated a pedunculated isodense mass below the tuber cinereum. T he hamartoma was totally removed using microsurgery. The symptoms and signs of precocious puberty disappeared after surgery. Follow-up MRI 1 year later showed no remaining tumor.