SYNTHESIS OF NOVEL MONOCYCLIC SQUALESTATIN ANALOGS AS POTENTIAL INHIBITORS OF SQUALENE SYNTHASE

Authors
SHAW RE BURGESS C COUSINS RPC GIBLIN GMP LIVERMORE DGH SHINGLER AH SMITH C YOUDS PM
Citation
Re. Shaw et al., SYNTHESIS OF NOVEL MONOCYCLIC SQUALESTATIN ANALOGS AS POTENTIAL INHIBITORS OF SQUALENE SYNTHASE, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2155-2160
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
18
Year of publication
1994
Pages
2155 - 2160
Database
ISI
SICI code
0960-894X(1994)4:18<2155:SONMSA>2.0.ZU;2-Z
Abstract
The syntheses of two monocyclic 1,3-dioxane tricarboxylic acid analogu es of the natural product srlualestatin 1 are described herein. Their activity against both mammalian (rat liver) and fungal (Candida albica ns) squalene synthase is also reported.