ACYCLIC NK1 ANTAGONISTS - REPLACEMENTS FOR THE BENZHYDRYL GROUP

Authors
SWAIN CJ CASCIERI MA OWENS A SAARI W SADOWSKI S STRADER C TEALL M VANNIEL MB WILLIAMS BJ
Citation
Cj. Swain et al., ACYCLIC NK1 ANTAGONISTS - REPLACEMENTS FOR THE BENZHYDRYL GROUP, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2161-2164
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
18
Year of publication
1994
Pages
2161 - 2164
Database
ISI
SICI code
0960-894X(1994)4:18<2161:ANA-RF>2.0.ZU;2-E
Abstract
An exploration of benzhydryl replacements is described. Whilst bridged and fused polynuclear aromatic systems both incur a reduction in affi nity it was possible to replace the benzhydryl by a single phenyl ring with only a modest reduction in affinity. In contrast to the analogou s diphenylalanyl ethers the binding was also shown to be stereoselecti ve.