DUAL METALLOPROTEASE INHIBITORS .4. UTILIZATION OF THIAZEPINES AND THIAZINES AS CONSTRAINED PEPTIDOMIMETIC SURROGATES IN MERCAPTOACYL DIPEPTIDES

Authors
DAS J ROBL JA REID JA SUN CQ MISRA RN BROWN BR RYONO DE ASAAD MM BIRD JE TRIPPODO NC PETRILLO EW KARANEWSKY DS
Citation
J. Das et al., DUAL METALLOPROTEASE INHIBITORS .4. UTILIZATION OF THIAZEPINES AND THIAZINES AS CONSTRAINED PEPTIDOMIMETIC SURROGATES IN MERCAPTOACYL DIPEPTIDES, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2193-2198
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
18
Year of publication
1994
Pages
2193 - 2198
Database
ISI
SICI code
0960-894X(1994)4:18<2193:DMI.UO>2.0.ZU;2-2
Abstract
A structure-activity study of the dual acting ACE/NEP inhibitors relat ed to la and Ib was undertaken to determine the parameters critical fo r activity versus ACE and NEP in vitro.