A COMPARATIVE MOLECULAR-FIELD ANALYSIS DERIVED MODEL OF THE BINDING OF TAXOL(R) ANALOGS TO MICROTUBULES

Authors
CZAPLINSKI KHA GRUNEWALD GL
Citation
Kha. Czaplinski et Gl. Grunewald, A COMPARATIVE MOLECULAR-FIELD ANALYSIS DERIVED MODEL OF THE BINDING OF TAXOL(R) ANALOGS TO MICROTUBULES, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2211-2216
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
18
Year of publication
1994
Pages
2211 - 2216
Database
ISI
SICI code
0960-894X(1994)4:18<2211:ACMADM>2.0.ZU;2-9
Abstract
We investigated a series of Taxol(R) (1, paclitaxel) analogues using a 3-D QSAR approach (CoMFA). Published and unpublished data for more th an 50 compounds have been included in the analysis and the model has b een used to predict the activity of other analogues. The model accurat ely describes known SARs and also has good predictive power.