TAXOL(R) STRUCTURE-ACTIVITY-RELATIONSHIPS - SYNTHESIS AND BIOLOGICAL EVALUATION OF TAXOL ANALOGS MODIFIED AT C-7

Authors
CHEN SH KANT J MAMBER SW ROTH GP WEI JM MARSHALL D VYAS DM FARINA V CASAZZA A LONG BH ROSE WC JOHNSTON K FAIRCHILD C
Citation
Sh. Chen et al., TAXOL(R) STRUCTURE-ACTIVITY-RELATIONSHIPS - SYNTHESIS AND BIOLOGICAL EVALUATION OF TAXOL ANALOGS MODIFIED AT C-7, Bioorganic & medicinal chemistry letters, 4(18), 1994, pp. 2223-2228
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
18
Year of publication
1994
Pages
2223 - 2228
Database
ISI
SICI code
0960-894X(1994)4:18<2223:TS-SAB>2.0.ZU;2-G
Abstract
A series of taxol derivatives, modified at C-7, is described. This inc ludes sulfonate, silylether, ester, carbonate, carbamate, fluoro, dehy dro and deoxy derivatives. Biological evaluation shows that these modi fications do not usually significantly compromise activity. However, n one of the C-7 analogs prepared thus far have been shown to be better than taxol in both in vitro and in vivo assays.