SYNTHESIS AND CHARACTERIZATION OF COPPER(II) COMPLEXES OF PHYSIOLOGICALLY ACTIVE TRIDENTATE SCHIFF-BASES

Copper complexes of 4-dihydroxyacetophenone-2-iminoethanethiol)(DAET), 2,4-dihydroxybenzophenone- 2-iminoethanethiol (DBET), 2,4-dihydroxyac etophenone-2-iminobenzenethiol (DABT) and 2,4-dihydroxybenzophenone-2- iminobenzene (DBBT) have been synthesized and characterized by element al analysis, conductivity, magnetic susceptibility measurements, IR, e lectronic and ESR spectral data The molar conductivity data show them to be non-electrolytes. The tridentate nature of the ligands is inferr ed from IR spectral studies. The electronic spectral data suggest plan ar geometry for all the complexes. Various ESR parameters have been ca lculated. The antibacterial activities of the ligands and their copper complexes have been screened in vitro against the organisms Escherchi a coli (E.C), Bacillus (B) and Pseudomonas aeruginosa (P.S). It is obs erved that the coordination of metal ions has pronounced effect on the bacterial activities of the ligands.