CHANGES IN ACUTE RELEASE OF T-PA AFTER CHRONIC ADMINISTRATION OF N-3 POLYUNSATURATED FATTY-ACIDS INTO RABBITS

The oral administration of a fish oil to rabbits leads to a decrease o f the tissue-type plasminogen activator (t-PA) activity in plasma. Tn order to investigate the possible causes of this effect a fish oil was fed during 4 weeks to rabbits and after that t-PA release was provoke d by the intravenous injection of epinephrine. Control animals were in jected by epinephrine without a pretreatment by a fish oil. The t-PA l iberator injection caused a significant, but a transient, increase in t-PA activity both in the fish oil-treated and untreated animals. Alth ough the basal activity of t-PA in the fish oil-treated animals was sm aller than in control rabbits, the release of this enzyme after drug s timulation was higher in this group as compared to the untreated anima ls. At 30 min after injection of epinephrine t-PA activity in the expe rimental animals was less than in control rabbits.