BACKGROUND. Even though 5-year cure rates are as high as 99% for Mohs
micrographic surgery (MMS) of cutaneous carcinomas, theoretically 100%
cure rates of unifocal carcinomas should be possible. OBJECTIVE. To d
etermine why cutaneous malignancies recur locally (persist) after MMS.
METHODS. A retrospective study of all cutaneous malignancies treated
with MMS during a 4-year period at Washington University School of Med
icine was made. All lesions that were locally recurrent after previous
MMS were analyzed for any possible cause of the recurrence. RESULTS.
Of 2,414 cutaneous malignancies treated, 33 (1.4%) were locally recurr
ent after previous MMS by four different Mohs surgeons and five separa
te technicians. Technical or interpretation problems that could have a
ccounted for the local recurrence were identified in 77% of the lesion
s. The mean time to recurrence was 38.5 months, with 20% developing mo
re than 5 years after the initial MMS. CONCLUSION. MMS local recurrenc
es are rare with procedural errors representing a majority of them. Fi
ve-year cure rates for basal cell carcinoma may somewhat overestimate
the ultimate cure rate.