SYNTHESIS AND RADIOPHARMACOLOGICAL STUDY OF NEW METALATED THIAZOLIDINES AND DITHIOACETALS OF N-ALLYL-SUBSTITUTED CYSTEAMINE AND METHYLCYSTEAMINE

Authors
RIMA G SATGE J SENTENACROUMANOU H FATOME M LAVAL JD LION C ALAZARD O CHABERTIER P
Citation
G. Rima et al., SYNTHESIS AND RADIOPHARMACOLOGICAL STUDY OF NEW METALATED THIAZOLIDINES AND DITHIOACETALS OF N-ALLYL-SUBSTITUTED CYSTEAMINE AND METHYLCYSTEAMINE, Applied organometallic chemistry, 8(5), 1994, pp. 481-490
Citations number
22
Categorie Soggetti
Chemistry Applied","Chemistry Inorganic & Nuclear
Journal title
Applied organometallic chemistry → ACNP
ISSN journal
02682605
Volume
8
Issue
5
Year of publication
1994
Pages
481 - 490
Database
ISI
SICI code
0268-2605(1994)8:5<481:SARSON>2.0.ZU;2-R
Abstract
New germa- and silathiazolidines or germa- and siladithioacetals with N-allyl-substituted cysteamine and methylcysteamine ligands have been synthesized and their pharmacological properties (toxicity, radioprote ctive activity) have been studied. A notable decrease in the toxicity and a rather large increase in the radioprotective activity of these n ew organometallic derivatives compared to N-allyl-substituted cysteami ne and methylcysteamine were observed.