A CANINE MODEL OF PANCREAS TRANSPLANTATION RECIPIENT FOLLOWING TOTAL PANCREATECTOMY AND ASSOCIATED LYMPHOPROLIFERATION

An attempt was made to use a diabetic dog as a model recipient of panc reas transplantation. The diabetic state was induced by total pancreat ectomy, and was shown to be stable by oral and intravenous glucose tol erance tests. In dogs that underwent total pancreatectomy under isoflu rane anesthesia (GOI) , blastogenesis of peripheral blood lymphocytes had a tendency to be reduced in comparison with non-treated dogs until 2 weeks after surgery. However, from 3 weeks after surgery, their res ponses became comparable to those of non-treated dogs. These results s uggest that stable diabetes mellitus is induced, in dogs, by total pan createctomy, and that this animal is a useful model of a pancreas tran splantation recipient.