EFFECTS OF SEX-HORMONE ON THE DILATATION OF URINARY TUBULE AND ACIDOPHIL BODY IN NON-MICE

The influences of sex hormones on the dilatation of the urinary tubule s and acidophil bodies were histologically investigated in NON (Non-Ob ese Non-diabetic)mice. Although the dilatation of the proximal tubules and acidophil bodies in NON mice were observed only in female but not in male, a slight dilatation and a few bodies were also observed in c astrated male NON mice. Moreover, in ovariectomized female NON mice th e dilatation and bodies were less compared with intact female NON mice . Estradiol administration induced prominent dilatation and numerous a cidophil bodies, while the administration of testosterone showed a com plete preventive effect. Therefore, it is suggested that the dilatatio n of the tubules and the acidophil bodies can be profoundly influenced by sex hormones.