Background: The prognosis of locally advanced pancreatic cancer is poo
r (median survival 3-5 months). In view of the localized character of
this disease several groups have explored the value of combined modali
ty treatment. The conditions are that a good local treatment and an ef
fective systemic treatment are available. Patients and methods: The re
sults of irradiation and of chemotherapy in advanced disease are revie
wed. Results: An overview of combined modality treatment has been give
n. Conclusions: Results of combined modality treatment are superior to
irradiation alone or to symptomatic treatment.