LICLO4 INDUCED ONE-POT 3-COMPONENT AMINOA LKYLATION OF ALDEHYDES

LiClO4-mediated one-pot reaction of isobutyraldehyde (1) or benzaldehy de (5) with (trimethylsilyl)dialkylamines 2 and C nucleophiles such as O-silylated ketene acetals 3, 6, allyl Grignard, lithium (trimethylsi lyl)acetylide, trimethylsilyl cyanide, and diethylzinc afforded in hig h yields the corresponding aminoalkylation products 4 and 7-13. The li thium enolate of cyclohexanone adds in 5 M LiClO4 solution in an lk ma nner to the corresponding mannich base (19, 20) with good yield.