COMPARISON OF BIOLOGICAL CHARACTERISTICS OF EDTMP COMPLEXES WITH TC-99M, IN-111 AND SM-153 IN RATS

Authors
LAZNICEK M LAZNICKOVA A BUDSKY F PROKOP J KOPICKA K
Citation
M. Laznicek et al., COMPARISON OF BIOLOGICAL CHARACTERISTICS OF EDTMP COMPLEXES WITH TC-99M, IN-111 AND SM-153 IN RATS, Applied radiation and isotopes, 45(9), 1994, pp. 949-953
Citations number
8
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
45
Issue
9
Year of publication
1994
Pages
949 - 953
Database
ISI
SICI code
0969-8043(1994)45:9<949:COBCOE>2.0.ZU;2-Y
Abstract
The pharmacokinetics and elimination of EDTMP chelates with different radionuclides (Tc-99m, In-111 and Sm-153) has been investigated in rat s. The biodistribution of the complexes under study was similar and tw o main processes, namely bone uptake and the elimination of glomerular filtration, take part in their rapid blood clearance. A substantially slower blood clearance of In-111-EDTMP in comparison with the other c omplexes suggests partial indium exchange between the chelate and tran sferrin. All the complexes exhibited high affinity for bent: and the r adionuclide uptake into the skeleton was in the order Sm-153 > In-111 > Tc-99m. No specific extra-skeletal uptake was found.