LINKAGE OF A NEW LOCUS FOR AUTOSOMAL-DOMINANT FAMILIAL SPASTIC PARAPLEGIA TO CHROMOSOME 2P

Authors
HAZAN J FONTAINE B BRUYN RPM LAMY C VANDEUTEKOM JCT RIME CS DURR A MELKI J LYONCAEN O AGID Y MUNNICH A PADBERG GW DERECONDO J FRANTS RR BRICE A WEISSENBACH J
Citation
J. Hazan et al., LINKAGE OF A NEW LOCUS FOR AUTOSOMAL-DOMINANT FAMILIAL SPASTIC PARAPLEGIA TO CHROMOSOME 2P, Human molecular genetics, 3(9), 1994, pp. 1569-1573
Citations number
29
Categorie Soggetti
Genetics & Heredity",Biology
Journal title
Human molecular genetics → ACNP
ISSN journal
09646906
Volume
3
Issue
9
Year of publication
1994
Pages
1569 - 1573
Database
ISI
SICI code
0964-6906(1994)3:9<1569:LOANLF>2.0.ZU;2-W
Abstract
Autosomal dominant familial spastic paraplegia (AD-FSP) is a genetical ly heterogeneous neurodegenerative disorder characterized by a spastic ity of the lower limbs. A locus causing AD-FSP (FSP1) has been previou sly mapped to chromosome 14q. We now report linkage of a second AD-FSP locus (FSP2) to chromosome 2p21-p24 in five of seven French families and one large Dutch pedigree. The analysis of recombination events and multipoint linkage place FSP2 within a 4 cM interval flanked by loci D2S400 and D2S367.