LOCALIZATION OF A GENE FOR AUTOSOMAL-DOMINANT AMELOGENESIS IMPERFECTA(ADAI) TO CHROMOSOME 4Q

Amelogenesis imperfecta (Al), is an inherited odontological disease wh ich affects the formation of enamel. We report a linkage analysis stud y performed on three Swedish families, where the affected members had an autosomal dominant variant of Al (ADAl) clinically characterized as local hypoplastic. Significant linkage to microsatellite markers on c hromosome 4q were obtained. Recombinations localized the ADAl locus to a chromosome region which contains both a locus for the dental disord er dentinogenesis imperfecta and the albumin gene. Serum albumin has b een suggested to play a role in enamel formation, and the albumin gene is therefore a candidate gene for this genetic disease.