DESIGN, SYNTHESIS, AND EVALUATION OF ORALLY-ACTIVE FIBRINOGEN INHIBITORS

Authors
TANAKA A SAKAI H ISHIKAWA T AOKI T MOROYAMA Y TAKASUGI H
Citation
A. Tanaka et al., DESIGN, SYNTHESIS, AND EVALUATION OF ORALLY-ACTIVE FIBRINOGEN INHIBITORS, Bioorganic & medicinal chemistry letters, 7(5), 1997, pp. 521-526
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
5
Year of publication
1997
Pages
521 - 526
Database
ISI
SICI code
0960-894X(1997)7:5<521:DSAEOO>2.0.ZU;2-V
Abstract
Low molecular weight and orally active fibrinogen inhibitors are descr ibed. The compounds studied in this work were rationally designed base d on a metabolic study of a peptidic fibrinogen inhibitor, 4-(4-amidin ophenoxy)butanoylaspartylvaline (1, FK633), which led to the synthesis of a potent and orally active antiplatelet agent, amidinophenoxy)buta noylaspartylvalylthiomorpholine 1,1-dioxide (3 f, FR158999). (C) 1997 Elsevier Science Ltd.