NOVEL 4-SUBSTITUTED PYRIDINE-DERIVATIVES - PRACTICAL DERIVATIZATION AND BIOLOGICAL PROFILES OF REVERSIBLE H+ K+-ATPASE INHIBITORS/

Authors
NIIYAMA K NAGASE T FUKAMI T TAKEZAWA Y TAKEZAWA H HIOKI Y TAKESHITA H ISHIKAWA K
Citation
K. Niiyama et al., NOVEL 4-SUBSTITUTED PYRIDINE-DERIVATIVES - PRACTICAL DERIVATIZATION AND BIOLOGICAL PROFILES OF REVERSIBLE H+ K+-ATPASE INHIBITORS/, Bioorganic & medicinal chemistry letters, 7(5), 1997, pp. 527-532
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
5
Year of publication
1997
Pages
527 - 532
Database
ISI
SICI code
0960-894X(1997)7:5<527:N4P-PD>2.0.ZU;2-1
Abstract
An easy method to prepare novel 4-alkoxy-, 4-alkylthio- or -methyl-2-[ 1-(hydroxy-methyl)-2-(1-naphthyl)-ethyl (or -ethenyl)]pyridine derivat ives having reversible inhibitory activity against H+/K+ ATPase is des cribed. Use of a methylsulfinyl- or methylsulfonyl group as a leaving group makes it possible to effectively introduce Various alkoxy or alk ylthio groups into the 4-position of the pyridine ring at the final st ages of synthesis. Biological profiles of the prepared compounds are b riefly mentioned. (C) 1997 Elsevier Science Ltd.