An easy method to prepare novel 4-alkoxy-, 4-alkylthio- or -methyl-2-[
1-(hydroxy-methyl)-2-(1-naphthyl)-ethyl (or -ethenyl)]pyridine derivat
ives having reversible inhibitory activity against H+/K+ ATPase is des
cribed. Use of a methylsulfinyl- or methylsulfonyl group as a leaving
group makes it possible to effectively introduce Various alkoxy or alk
ylthio groups into the 4-position of the pyridine ring at the final st
ages of synthesis. Biological profiles of the prepared compounds are b
riefly mentioned. (C) 1997 Elsevier Science Ltd.