FLOW-INJECTION EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF IMIPRAMINE IN PHARMACEUTICALS WITH METHYL-ORANGE

Authors
PEREZRUIZ T MARTINEZLOZANO C SANZ A ALONSO C
Citation
T. Perezruiz et al., FLOW-INJECTION EXTRACTION-SPECTROPHOTOMETRIC DETERMINATION OF IMIPRAMINE IN PHARMACEUTICALS WITH METHYL-ORANGE, Talanta, 41(9), 1994, pp. 1523-1527
Citations number
31
Journal title
Talanta
ISSN journal
00399140 → ACNP
Volume
41
Issue
9
Year of publication
1994
Pages
1523 - 1527
Database
ISI
SICI code
0039-9140(1994)41:9<1523:FEDOI>2.0.ZU;2-F
Abstract
Imipramine in aqueous solution is extracted into 1,2-dichloroethane as its ion-pair with Methyl Orange in an unsegmented flow system and qua ntified spectrophotometrically. A linear calibration graph was obtaine d between 0.79 and 25.3 mug/ml of imipramine. Up to 45 samples/hr can be processed with a RSD of 0.88-1.6%. The method was satisfactorily ap plied to the determination of imipramine in pharmaceutical preparation s.