DESIGN AND SYNTHESIS OF NEW TAXOL-CONTAINING AMINOPHOSPHATES AS PROTAXOLS

Authors
HWU JR HAKIMELAHI GH SAMBAIAH T PATEL HV TSAY SC LAI YK LIEU CH
Citation
Jr. Hwu et al., DESIGN AND SYNTHESIS OF NEW TAXOL-CONTAINING AMINOPHOSPHATES AS PROTAXOLS, Bioorganic & medicinal chemistry letters, 7(5), 1997, pp. 545-548
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
5
Year of publication
1997
Pages
545 - 548
Database
ISI
SICI code
0960-894X(1997)7:5<545:DASONT>2.0.ZU;2-D
Abstract
Taxol-containing aminophosphates 5-7 were synthesized as protaxols by a ''one-flask'' method; the intrinsic zwitterionic character increases their solubility to about six times higher than that of taxol in a ph osphate buffer solution. (C) 1997 Elsevier Science.