STUDY OF THE IN-VIVO BIOLOGICAL-ACTIVITY OF HUMAN RECOMBINANT INTERLEUKIN-1-BETA

Authors
SIMBIRTSEV AS PIGAREVA NV KONUSOVA VG KALININA NM SOROKIN YM KETLINSKY SA
Citation
As. Simbirtsev et al., STUDY OF THE IN-VIVO BIOLOGICAL-ACTIVITY OF HUMAN RECOMBINANT INTERLEUKIN-1-BETA, VESTNIK ROSSIISKOI AKADEMII MEDITSINSKIKH NAUK, (2), 1993, pp. 18-22
Citations number
20
Categorie Soggetti
Medicine, General & Internal
Journal title
VESTNIK ROSSIISKOI AKADEMII MEDITSINSKIKH NAUK → ACNP
ISSN journal
08696047
Issue
2
Year of publication
1993
Pages
18 - 22
Database
ISI
SICI code
0869-6047(1993):2<18:SOTIBO>2.0.ZU;2-5
Abstract
Human recombinant IL-1beta injected intraperitoneally into CBA mice do se-dependently induced leukocytosis, stimulated phagocytosis and reduc ed tetrazolium nitroblue by peritoneal leukocytes, colony formation by bone marrow cells, enhanced Con A and IL-2-induced proliferation and IL-2 production in thymocytes and splenocytes. Recombinant IL-1beta re stored bone marrow cell proliferation reduced after 5-fluorouracil tre atment and significantly increased the survival rates of lethally irra diated mice.