EFFECT OF RECOMBINANT INTERLEUKIN-1-BETA ON THE CHEMOTACTIC ACTIVITY OF NEUTROPHILIC LEUKOCYTES

Authors
KONUSOVA VG SIMBIRTSEV AS KETLINSKY SA
Citation
Vg. Konusova et al., EFFECT OF RECOMBINANT INTERLEUKIN-1-BETA ON THE CHEMOTACTIC ACTIVITY OF NEUTROPHILIC LEUKOCYTES, VESTNIK ROSSIISKOI AKADEMII MEDITSINSKIKH NAUK, (2), 1993, pp. 27-29
Citations number
19
Categorie Soggetti
Medicine, General & Internal
Journal title
VESTNIK ROSSIISKOI AKADEMII MEDITSINSKIKH NAUK → ACNP
ISSN journal
08696047
Issue
2
Year of publication
1993
Pages
27 - 29
Database
ISI
SICI code
0869-6047(1993):2<27:EORIOT>2.0.ZU;2-S
Abstract
The role of interleukin-1 in the activation of neutrophils, the main e ffects of inflammatory reaction, is still unclear. This study has demo nstrated that the recombinant preparation interleukin-1beta (IL-1beta) which the authors have obtained fails to produce a direct action on t he locomotor functions of neutrophils. At the same time, injection of IL-18 in mice leads to neutrophilic migration to the injection site an d their efflux into peripheral blood. These findings confirm the assum ption that interleukin-1 produces a mediatory effect on neutrophilic c hemotaxis.