IMMUNE-RESPONSES TO SUPEROXIDE-DISMUTASE AND SYNTHETIC PEPTIDES OF SUPEROXIDE-DISMUTASE IN CATTLE VACCINATED WITH BRUCELLA-ABORTUS STRAIN-19 OR STRAIN-RB51
Mg. Stevens et al., IMMUNE-RESPONSES TO SUPEROXIDE-DISMUTASE AND SYNTHETIC PEPTIDES OF SUPEROXIDE-DISMUTASE IN CATTLE VACCINATED WITH BRUCELLA-ABORTUS STRAIN-19 OR STRAIN-RB51, Veterinary microbiology, 41(4), 1994, pp. 383-389
Antibody and lymph node cell-mediated immune responses to recombinant
Brucella abortus strain 19 Cu-Zn superoxide dismutase (rSOD) and to th
ree synthetic strain 19 Cu-Zn SOD peptides were measured during 2 to 1
2 weeks following vaccination of cattle with B. abortus strain 19 or R
B51. Cattle vaccinated with strain 19 or RB51 did not produce antibody
to rSOD and to the SOD peptides. Lymph node cells from cattle vaccina
ted with strain 19, but not with strain RB51, proliferated when incuba
ted with either rSOD or one of the three tested SOD peptides (GGDNYSDK
PEPLGG). These results suggest that neither the strain 19 nor the stra
in RB51 vaccine induces antibody production to SOD and only the strain
19 vaccine induces lymph node cell-mediated immune responses to SOD.