ACCUMULATION OF PLATINUM IN THE INTERVERTEBRAL DISKS AND VERTEBRAE OFOVARIAN TUMOR-BEARING PATIENTS TREATED WITH CISPLATIN

Platinum was determined by the inductively coupled plasma mass spectro metry (ICP-MS) in the intervertebral discs and vertebrae of ovarian tu mor bearing patients treated with cis-diamminedichloro-platinum (II) ( cisplatin). Platinum was 0.05 ng/mL at the absolute detection limit, a nd platinum was undetectable in the intervertebral discs and vertebrae of human specimens without cisplatin treatments. On the other hand, p latinum was detected in the intervertebral discs and vertebrae of pati ents administered cisplatin, and platinum concentration was at levels of 1.06-10.31 mu g/g dry tissue in the intervertebral discs and 0.60-1 .28 mu g/g dry tissue in the vertebrae, respectively. The platinum lev el of intervertebral discs was 4.3-fold higher than that of the verteb rae. Thus, platinum accumulates greatly in the intervertebral discs an d somewhat in the vertebrae after administering cisplatin to patients for therapy.