Relatively few studies have investigated the prevalence of insect-stin
g allergy and the results of diagnostic procedures in unselected popul
ations. The prevalence of insect-sting reactions and of venom sensitiz
ation in Greece is unknown We report the results from a stratified ran
dom sample of 480 subjects (404 men, 76 women), aged 20-60 years. They
all belonged to the ground personnel of the Hellenic Air Force. A det
ailed history particularly focused on the reactions to Hymenoptera sti
ngs was taken in all subjects. Intradermal skin tests (concentration:
1 mu g/ml) with three venoms (honeybee, paper wasp, common wasp) were
performed. The prevalence of venom sensitization (one or more positive
skin tests) was 32.7%. Sensitization appears to be more common (2.69
times) in those Living in rural areas than in those living in the capi
tal (Athens). The prevalence of systemic reactions was 3.1% (86.7% of
them had positive skin tests). Large local reactions were reported by
4.6% of the subjects (77.3% of them had positive skin tests). Asymptom
atic sensitization (positive skin tests to venoms) was observed in 28.
7% of subjects with no history of an allergic sting reaction. We concl
uded that the prevalence of Hymenoptera allergy and venom sensitizatio
n in Greece is rather high compared to that of other countries.