AUTONOMIC NEUROPATHY AND TRANSCUTANEOUS OXYMETRY IN DIABETIC LOWER-EXTREMITIES

Transcutaneous oxygen tension is a useful method with which to assess the functional status of skin blood flow. The reduced values observed in diabetic patients have been interpreted as a consequence of periphe ral vascular disease. However, diabetic patients show lower transcutan eous oxygen tension values than control subjects with equivalent degre es of peripheral vascular disease, suggesting that additional factors are involved. Since the autonomic nervous system influences peripheral circulation, we studied the relationship between autonomic neuropathy and foot transcutaneous oxymetry in non-insulin-dependent diabetic (N IDDM) patients without peripheral vascular disease. The following age- matched patients were selected and evaluated: control subjects, C, (n = 20), NIDDM patients without autonomic neuropathy, D, (n = 16) and wi th autonomic neuropathy, DN, (n = 20). All diabetic patients showed lo wer transcutaneous oxygen tension values than control subjects, while no differences were observed between the diabetic patients with and wi thout autonomic neuropathy. In addition the saturation index that incr eases in the presence of autonomic neuropathy does not correlate with foot TcPO2. In conclusion autonomic neuropathy does not influence foot TcPO2 and therefore it is unlikely that it contributes to development of foot lesions during induction of foot skin ischaemia.