The number of osteoporotic fractures is rising in men and women, becau
se of the demographic trend towards an aging population and an increas
e in the age-specific incidence of fractures. Although previous studie
s have examined the morbidity following hip fractures in women, there
is little information on the sequelae of vertebral crush fractures in
men. We have therefore collected data on loss of height, kyphosis, per
ipheral fractures and functional status in 63 men with symptomatic ver
tebral fractures. Loss of height was documented in 49% of the men, whi
le kyphosis was present in 54%. A past history of 50 non-vertebral fra
ctures was obtained in 27 patients (43%), involving the ribs (17), low
er arm (13) and femoral neck (4). Each patient then completed the Nott
ingham Health Profile (NHP), which gives information on perceived heal
th. Men with vertebral crush fractures had higher scores for all six d
omains of the NHP when compared with age-matched and more elderly cont
rol subjects, implying greater morbidity. This was particularly marked
for the energy, pain and mobility domains of the NHP. We conclude tha
t there is considerable morbidity associated with vertebral crush frac
tures in men, which should be assessed in any trial of therapeutic int
ervention. This study suggests that the NHP may be a useful instrument
in this regard.