THE REGULATION OF SODIUM-DEPENDENT TRANSPORT OF ANIONIC AMINO-ACIDS IN CULTURED HUMAN FIBROBLASTS

Authors
FRANCHIGAZZOLA R VISIGALLI R BUSSOLATI O GAZZOLA GC
Citation
R. Franchigazzola et al., THE REGULATION OF SODIUM-DEPENDENT TRANSPORT OF ANIONIC AMINO-ACIDS IN CULTURED HUMAN FIBROBLASTS, FEBS letters, 352(2), 1994, pp. 109-112
Citations number
26
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
352
Issue
2
Year of publication
1994
Pages
109 - 112
Database
ISI
SICI code
0014-5793(1994)352:2<109:TROSTO>2.0.ZU;2-T
Abstract
In cultured human fibroblasts the transport of anionic amino acids thr ough the sodium-dependent system X(AG)(-) is stimulated rapidly and tr ansiently by phorbol 12,13-dibutyrate. Transport stimulation is consis tent with an effect due to the activation of protein kinase C. Bradyki nin (1 mu M) and PDGF-AA (100 ng/ml) also stimulate the activity of sy stem X(AG)(-). The bradykinin effect appears to be fully dependent upo n PKC activation whereas the stimulation of aspartate transport by PDG F-AA is also due to PKC-independent mechanisms.