NEUROENDOCRINE REGULATION OF FEEDING-BEHA VIOR

We review current neuroendocrine concepts about feeding behavior. Dige stive or metabolic inputs are conveyed to the hypothalamus by endocrin e and neuroendocrine pathways (insulin, cholecystokinin). The hypothal amus regulates feeding behavior both quantitatively and qualitatively through several neuroendocrine mediators (neuropeptide Y, galanin, GHR H...). The hypothalamus also integrates, by its communicative network, inputs from the cortex, the sub-cortex, the peripheral metabolism and it modifies consequently the feeding behavior. These neuroendocrine m odels are developped from many experimental observations both in norma l and obese animals.