BIOCIDAL ACTION OF CHLORHEXIDINE IS ANNULLED BY NICOTINIC-ACID

Authors
BAKER H FRANK O DEANGELIS B BAKER ER
Citation
H. Baker et al., BIOCIDAL ACTION OF CHLORHEXIDINE IS ANNULLED BY NICOTINIC-ACID, Antimicrobial agents and chemotherapy, 38(10), 1994, pp. 2458-2459
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
10
Year of publication
1994
Pages
2458 - 2459
Database
ISI
SICI code
0066-4804(1994)38:10<2458:BAOCIA>2.0.ZU;2-P
Abstract
An analytical system comprising a bacterium and a protozoan was used t o pinpoint the metabolic lesion whereby chlorhexidine (CLX) produced c ell death. Nicotinic acid but not nicotinamide annulled the biocidal a ction of CLX. The results suggest that CLX may not permit bioconversio n of nicotinamide to nicotinic acid to annul the growth inhibition ind uced by CLX.