EFFICACIES OF DIFFERENT VANCOMYCIN DOSING REGIMENS AGAINST STAPHYLOCOCCUS-AUREUS DETERMINED WITH A DYNAMIC IN-VITRO MODEL

A dynamic in vitro model was used to assess four different vancomycin dosing regimens against Staphylococcus aureus. These regimens achieved peak drug concentrations of 48 mu g/ml (single dose) and 30 mu g/ml ( dosed every 12 h) and constant concentrations of 16 and 8 mu g/ml. Ana lysis of the area under the bacterial concentration-time curve, area u nder the first moment of the bacterial concentration-time curve, and b acterial elimination rate constant showed no difference in the rate or extent of bacterial killing. The optimal dosing method may be that wh ich achieves the lowest area under the curve while concentrations are maintained above the MBC.