INHIBITION OF GP120-CD4 INTERACTION AND HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN-VITRO BY PYRIDOXAL 5'-PHOSPHATE

Authors
GUO L HEINZINGER NK STEVENSON M SCHOPFER LM SALHANY JM
Citation
L. Guo et al., INHIBITION OF GP120-CD4 INTERACTION AND HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION IN-VITRO BY PYRIDOXAL 5'-PHOSPHATE, Antimicrobial agents and chemotherapy, 38(10), 1994, pp. 2483-2487
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
38
Issue
10
Year of publication
1994
Pages
2483 - 2487
Database
ISI
SICI code
0066-4804(1994)38:10<2483:IOGIAH>2.0.ZU;2-N
Abstract
Pyridoxal 5'-phosphate and related compounds were tested for their abi lity to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presen ce of both lysine-reactive and anionic substituents.