AZOLE RESISTANCE IN OROPHARYNGEAL CANDIDA-ALBICANS STRAINS ISOLATED FROM PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS

For 212 oropharyngeal isolates of Candida albicans, the fluconazole MI Cs for 50 and 90% of strains tested were 0.5 and 16 mu g/ml, respectiv ely, and those of itraconazole were 0.05 and 0.2 mu g/ml, respectively . Of 16 isolates for which fluconazole MICs were >64 mu g/ml, itracona zole MICs for 14 were less than or equal to 0.8 mu g/ml and for 2 were >6.4 mu g/ml. Most fluconazole-resistant strains remained susceptible to itraconazole;,whether itraconazole will prove effective for refrac tory thrush remains to be shown.