IN-VITRO ACTIVITIES OF 2 NEW GLYCYLCYCLINES, N,N-DIMETHYLGLYCYLAMIDO DERIVATIVES OF MINOCYCLINE AND 6-DEMETHYL-6-DEOXYTETRACYCLINE, AGAINST339 STRAINS OF ANAEROBIC-BACTERIA

The in vitro activities of the N,N-dimethylglycylamido derivatives of minocycline (DMG-MINO) and 6-demethyl-6-deoxytetracycline (DMG-DMDOT) were compared with those of minocycline, tetracycline, clindamycin, an d metronidazole by using the National Committee for Clinical Laborator y Standards-approved Wadsworth agar dilution method. The MICs of DMG-M INO, DMG-DMDOT, and metronidazole at which 90% of the strains mere sus ceptible (0.5, 1, and 1 mu g/ml, respectively) were lower than those f or clindamycin, minocycline, and tetracycline (4, 8, and 32 mu g/ml, r espectively). All of the strains of anaerobes tested, except one strai n of Bacteroides ovatus (MIC, 16 mu g/ml), were susceptible to DMG-MIN O and DMG-DMDOT at 8 mu g/ml.