DETOXICATION OF THE 2',3'-EPOXIDE METABOLITES OF ALLYLBENZENE AND ESTRAGOLE - CONJUGATION WITH GLUTATHIONE

Authors
LUO G GUENTHNER TM
Citation
G. Luo et Tm. Guenthner, DETOXICATION OF THE 2',3'-EPOXIDE METABOLITES OF ALLYLBENZENE AND ESTRAGOLE - CONJUGATION WITH GLUTATHIONE, Drug metabolism and disposition, 22(5), 1994, pp. 731-737
Citations number
32
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug metabolism and disposition → ACNP
ISSN journal
00909556
Volume
22
Issue
5
Year of publication
1994
Pages
731 - 737
Database
ISI
SICI code
0090-9556(1994)22:5<731:DOT2MO>2.0.ZU;2-6
Abstract
The enzymatic detoxication in vitro of the 2',3'-epoxide derivatives o f allylbenzene and estragole was examined, and the relative rates of e nzymatic glutathione conjugation and epoxide hydrolysis were compared with those for styrene 1',2'-oxide. HPLC was used to determine the amo unts of dihydrodiol end glutathione conjugate metabolites formed by ce ll extracts from several sources. Although