S. Quenby et Rg. Farquharson, HUMAN CHORIONIC-GONADOTROPIN SUPPLEMENTATION IN RECURRING PREGNANCY LOSS - A CONTROLLED TRIAL, Fertility and sterility, 62(4), 1994, pp. 708-710
Objectives: To investigate the efficacy of hCG in the management of re
current early pregnancy loss. Design: A prospective, randomized, contr
olled trial. Setting: Miscarriage Clinic, Women's Hospital, Liverpool,
United Kingdom. Subjects: Eighty-one women attending the miscarriage
clinic with idiopathic recurrent pregnancy loss were randomized to rec
eive hCG supplementation or placebo in early pregnancy. Main Outcome M
easure: The success rate or live birth rate. Results: In women with re
gular menstrual cycles it was found that hCG had no beneficial effect,
the pregnancy success rate being 86% in both groups. However, women w
ith oligomenorrhea had a pregnancy success rate of 40% in the placebo
group but a statistically significant improvement to 86% if hCG was gi
ven. Conclusions: Human chorionic gonadotropin can be recommended for
idiopathic recurrent pregnancy loss in women with oligomenorrhea.