Many victims of accidental hypothermia have been successfully resuscit
ated with cardiopulmonary bypass, but questions remain regarding treat
ment indications and efficacy. To assess the role of cardiopulmonary b
ypass in resuscitation frog hypothermia a collective literature review
was performed. Data on 68 hypothermic patients resuscitated with card
iopulmonary bypass were analyzed. Impairment from alcohol, drug abuse,
or mental illness was the most common predisposing factor for acciden
tal hypothermia. Mean initial core temperature was 21 degrees C. Sixty
-one patients (90%) were in cardiac arrest. Femoral-femoral bypass was
used in 72% of patients. Overall survival was 60%. Eighty percent of
survivors returned to their previous level of function. Sixty-seven pe
rcent of nonsurvivors died because of inability to establish a cardiac
rhythm or wean from bypass. Patient age, type of cardiopulmonary bypa
ss (femoral-femoral or atrial-aortic), and initial core temperature we
re not significant prognostic indicators. There were no survivors amon
g the 6 patients with a core temperature less than 15 degrees C. Patie
nts in cardiac arrest had a higher mortality than patients who were no
t (p = 0.02). Climbing and avalanche victims had a higher mortality th
an other hypothermic patients (p = 0.003). The possibility of publicat
ion bias must be considered before firm conclusions can be drawn from
this collective literature review. Controlled studies comparing the ef
ficacy of cardiopulmonary bypass and alternative warming techniques ha
ve not been done. Nevertheless, cardiopulmonary bypass has several adv
antages over other warming methods for profoundly hypothermic patients
. Tissue perfusion and oxygenation are maintained while rapid warming
occurs. Cardiopulmonary bypass resuscitation is recommended for hypoth
ermic patients in arrest and for patients with core temperatures lower
than 25 degrees C, irrespective of rhythm. Patients in stable conditi
on with temperatures between 25 degrees and 28 degrees C can be treate
d with cardiopulmonary bypass or conventional warming methods.