EPSTEIN-BARR-VIRUS TYPE-1 AND TYPE-2 HAVE NEARLY IDENTICAL LMP-1 TRANSFORMING GENES

Although variation in the gene encoding the Epstein-Barr virus (EBV) n uclear protein 2 accounts for much of the difference in the transformi ng activities of the two EBV strain types, divergence in the principal lymphocyte growth-altering gene, LMP-1, has not been previously evalu ated. We have now determined the nucleotide sequence of the LMP-1 gene of a type 2 isolate of EBV, AG876. Surprisingly, the AG876 LMP-1 prot ein is 93 % identical to the prototype type 1 EBV strain B95-8, and th is is well within the range of variability previously noted among type 1 EBV LMP-1 genes.