DENDRIMER ELECTROKINETIC CAPILLARY CHROMATOGRAPHY - UNIMOLECULAR MICELLAR BEHAVIOR OF CARBOXYLIC-ACID TERMINATED CASCADE MACROMOLECULES

Dendritic (cascade) macromolecules with carboxylic acid terminal moiet ies are examined as micellar substitutes for the separation of a homol ogous series of alkyl parabens via electrokinetic capillary chromatogr aphy employing aqueous mobile phase conditions; separations using the dendrimers yield excellent efficiency and, resolution, while higher ge neration dendrimers,demonstrate enhanced affinity for the parabens rel ative to lower generation dendrimers and so provide superior separatio ns under identical conditions; the cascades are also shown to be sensi tive to solution pH and the technique is extended to the separation of components found in a common cough medicine.