SYNTHESIS AND PROPERTIES OF (1-AZABICYCLO[2.2.2]OCT-3-YL)-ALPHA-(METHOXYIMINO) ACETONITRILE, A NOVEL FUNCTIONALLY SELECTIVE MUSCARINIC PARTIAL AGONIST())

The (Z)-N-methoxy imidoyl nitrile functionality is a novel methyl este r bioisostere, which, when substituted onto the quinuclidine ring syst em gives the title compound 1, a stable, brain penetrant and functiona lly selective muscarinic; partial agonist; X-ray studies confirm the c onfigurational assignment and reveal that the imino and cyano bond len gths are consistent with those expected for formal double and triple b onds, respectively.