MILD ALCOHOL METHYLATION PROCEDURES FOR THE SYNTHESIS OF POLYOXYGENATED NATURAL-PRODUCTS - APPLICATIONS TO THE SYNTHESIS OF LONOMYCIN-A

Authors
EVANS DA RATZ AM HUFF BE SHEPPARD GS
Citation
Da. Evans et al., MILD ALCOHOL METHYLATION PROCEDURES FOR THE SYNTHESIS OF POLYOXYGENATED NATURAL-PRODUCTS - APPLICATIONS TO THE SYNTHESIS OF LONOMYCIN-A, Tetrahedron letters, 35(39), 1994, pp. 7171-7172
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
39
Year of publication
1994
Pages
7171 - 7172
Database
ISI
SICI code
0040-4039(1994)35:39<7171:MAMPFT>2.0.ZU;2-B
Abstract
Studies directed toward the formation of methyl ethers in key intermed iates for the synthesis of lono-mycin A are described. Several highly functionalized secondary alcohols have been methylated in excellent yi elds using the powerful methylating reagents methyl triflate (MeOTf) a nd trimethyloxonium fluoroborate (Me(3)OBF(4)).