POSTINFANTILE GIANT-CELL HEPATITIS ASSOCIATED WITH ANTI-M2 MITOCHONDRIAL ANTIBODIES

Whereas giant cell hepatitis (GCH) is a common diagnosis made in neona tes, it is rare in the adult population. The diagnosis of GCH is based on the presence of giant cell transformation of hepatocytes. It is co mmonly associated with either viral hepatitis or autoimmune disorders. A patient with GCH who had anti-M2 mitochondrial antibodies is descri bed. This combination, which has not been previously reported, undersc ores the association of GCH with autoimmune disorders and stresses the importance of corticosteroids as an empirical initial therapy.