Ia. Paterson et al., (-)DEPRENYL REDUCES DELAYED NEURONAL DEATH OF HIPPOCAMPAL PYRAMIDAL CELLS, Neuroscience and biobehavioral reviews, 21(2), 1997, pp. 181-186
Ischemia-induced delayed neuronal death can be mediated by apoptosis,
and (-)deprenyl has been shown to block apoptosis in dopaminergic and
cholinergic neurons. This study has investigated whether (-)deprenyl c
an prevent delayed neuronal death of hippocampal pyramidal cells. Rats
were subjected to unilateral hypoxia-ischemia and treated with (-)dep
renyl (0.25 mg/kg, s.c.) or saline daily. After sacrifice the left and
right hippocampi were examined histologically. Unilateral delayed neu
ronal death was seen in the CA1, CA3 and CA4 fields up to 14 days afte
r the ischemia. After 14 days' treatment with (-)deprenyl there was 66
%, 91% and 96% reduction in delayed neuronal death in the CA1, CA3 and
CA4 fields, respectively. (-)Deprenyl was effective when given at the
onset or after ischemia, but not when given 2 h before ischemia. The
reduction in ischemia-induced delayed neuronal death is consistent wit
h an anti-apoptotic mechanism of (-)deprenyl. (C) 1997 Published by El
sevier Science Ltd. All rights reserved.