NUMBER OF FOLLICLES, OOCYTES AND EMBRYOS IN HUMAN IN-VITRO FERTILIZATION IS RELATIVE TO SERUM ESTRADIOL AND PROGESTERONE PATTERNS DURING DIFFERENT TYPES OF OVARIAN HYPERSTIMULATION
E. Suchanek et al., NUMBER OF FOLLICLES, OOCYTES AND EMBRYOS IN HUMAN IN-VITRO FERTILIZATION IS RELATIVE TO SERUM ESTRADIOL AND PROGESTERONE PATTERNS DURING DIFFERENT TYPES OF OVARIAN HYPERSTIMULATION, European journal of obstetrics, gynecology, and reproductive biology, 56(2), 1994, pp. 121-127
Preovulatory serum estradiol and progesterone levels as well as their
ratio were compared in different types of ovulation induction in order
to determine whether these findings could be used to predict the numb
er of preovulatory follicles, number of oocytes aspirated and embryos
obtained. Significantly more oocytes were retrieved by follicular aspi
ration and significantly more embryos developed in patients receiving
gonadotropin-releasing hormone agonist and human menopausal gonadotrop
ins than in those given other ovulation inductors. On days -2 and -1 o
f the cycle, serum estradiol levels were significantly lower in pure f
ollicle-stimulaing hormone induction. Serum progesterone was significa
ntly higher in pure follicle-stimulating hormone cycles on days -4 and
-3. In clomiphene citrate and human menopausal gonadotropin induction
, progesterone levels were significantly lower on days -2 and -1, and
on the day of follicular aspiration. Ratios of estradiol/progesterone
were lower in pure follicle-stimulating hormone group from day -3 to d
ay -1 of the cycle. A significant correlation was found between estrad
iol and progesterone serum levels and the numbers of preovulatory foll
icles, oocytes and embryos. The study revealed the usefulness of serum
estradiol and progesterone determinations in assisted reproduction.