Y. Takahashi et al., N-METHYL-D-ASPARTATE RECEPTORS CONTRIBUTE TO AFFERENT SYNAPTIC TRANSMISSION IN THE MEDIAL VESTIBULAR NUCLEUS OF YOUNG-RATS, Brain research, 659(1-2), 1994, pp. 287-291
In the medial vestibular nucleus (MVN), the non-N-methyl-D-aspartate (
NMDA) subtype of ionotropic glutamate receptors has been reported as o
perating at synapses between ipsilateral vestibular afferents and neur
ons. In the present study, we addressed the question of whether or not
NMDA receptors contribute to afferent synaptic transmission in the MV
N and if so, to what degree. Using nystatin-perforated or conventional
whole-cell patch clamp methods in brainstem slices of young rats (pos
tnatal day 4-6), we found that NMDA receptors contribute to a substant
ial extent to afferent synaptic transmission in the MVN of young rats.